Collagen, the most biocompatible material
Collagen is the major protein in connective tissues and is widely used as biomedical material. Biomedical material for dermal implant should possess the following criteria: controllable degradation rate; excellent biocompatibility; appropriate mechanical strength; no immune rejection and promote tissue regeneration. Among these, biocompatibility and immunity are the most important issues.
The medical application of collagen was recorded in the early 20 th century. Due to the high biocompatibility, low immunity, physically absorbability and degradability, and its rapid wound healing effect, collagens have been utilized widely in many reconstruction surgeries.
Very rare immune response of collagen
The structure of collagen is highly regular. Three helix chains constituted by an orderly combination of Gly-X-Y amino acids intertwine to form a collagen molecule with a triple helix structure. Collagen is the primary structure in human skin dermis that exists extensively in human connective tissues and vital organs through a repetitive arrangement.
Through purification treatment with enzyme and special innovation modification technology, purified collagen has very rare immune response. In addition, the mechanical strength of collagen has also been reinforced through the
innovation modification technology. The application of such technology provide durable filler effect.
The proliferation and repair functions of collagen
Another benefit of collagen is to enhance wound healing by inducing the self-repair ability. Through a unique technology that purifies collagen, collagen has become highly biocompatible and play an important role in blood coagulation during the early wound healing phase, which in turn reduces inflammation time. On the other hand, collagen can also induce the proliferation of healthy cells around the wound to provide the structure for tissue growth. Cells can attach to the matrix and grow into new tissues. Therefore, collagen has been applied extensively in tissue engineering including reconstruction of soft or hard tissues.
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Collagen Bone Graft |
Collagen Dental Membrane |
Collagen Wound Dressing |
Studies have also claimed that tissue correction through the implantation of collagen in dermis not only creates a tridimensional space to recover skin elasticity; the implanted collagens will also enhance the migration and attachment of fibroblasts and proliferation of which in turn secrets body's own collagen.